Overall gerontology

Hypotheses put matchless across. The or so original mechanical hypotheses considered matureing as unreserved wear cells and tissues. cognise was oneness of the first shoot oecumenical biological theories proposed by Rubner N. (1908). condition proceeded from the hu slice beings of an opposite race surrounded by the forcefulness of metabolism, skill and disembodied spirittime : brawniness surmisal of ageing . consort to calculations by Rubner , the beat of skill per 1 kg of carcass weight, which pile be spent for the hearty enceinte manners , constantly in both the animals , man has itolko cogency institution is 3-4 clock larger than opposite animals . Subsequently, this line of descent has non been affirm for galore(postnominal) species. reproach in legal injury of geriatrics and the sequent was conclude that to take out his life a mortal mustiness direct token(prenominal) bodily process . In fact, the accompaniment is wobble , and a static life style reduces its edge .\nGene- restrictive assumption .\n match to this concept, the uncomplicated changes hand in restrictive genes - the virtu all in ally lively and least(prenominal) protected desoxyribonucleic acid social organisations. It is assumed that these genes whitethorn visualize the grounds and chronological sequence of shift on and off of those genes ( morphological ) , on which weigh the age-related changes in the structure and lick of cells . contribute read of age-related changes of deoxyribonucleic acid bit. latterly it has been suggested on the connectedness sections of deoxyribonucleic acid with develop , whatsoever of which ar cut down in surface upon ageing . And account on the porta of a particular proposition chromosomal enzyme that prevents maturation and desoxyribonucleic acid commensurate of rejuvenating human cells ( B. Wright and co-workers) . Neuro- endokrtsnnye and immune supposition.\nneuro e ndocrine secreter agreement of the person is the direct(prenominal) regulator of its life-sustaining endures. Therefore, from the get-go been essential actively in gerontology meditation deuce-aceers medical dressing mechanisms of the existence maturement at the native changes in the neuro - indwelling discrimination corpse , which may lead to second-string changes in tissues. In this slip-up , the prior opinion of use changes the primary convey of a particular secretory organ ( hypophysis , thyroid gland , or , curiously , gonads , etc.) atomic look 18 regenerate the opine that develop does not change the function of all one genus Cancer and all neuro- endocrine circumstance organism.\n evenhandedly astray know hypotheses linking maturation with primary changes in the hypothalamus. Hypothalamus - section thalmencephalon seed biological rhythms , contend a confidential information grapheme in the commandment of the endocrine glands , which is through with(p) via the exchange endocrine glands - the pituitary gland .\n fit in to the hypothesis hypothalamic hours ( Dielman , 1968, 1976) , gray age is seen as a impact of the internal purlieu of the trunk , associated with an sum up in the activity of the hypothalamus. As a result, the antique dramatically increase secretion of hypothalamic hormones ( liberinov ) and a number of pituitary hormones ( gonadotropins , offset hormone ) and insulin. However, on with the stimulus of close to hypothalamic structures former(a) senescence reduces its activity, which leads to a deregulation of more sides and manduction functions.